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LY6E

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LY6E
Identifiers
AliasesLY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDsOMIM: 601384; MGI: 106651; HomoloGene: 56411; GeneCards: LY6E; OMA:LY6E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002346
NM_001127213

RefSeq (protein)

NP_001120685
NP_002337

Location (UCSC)Chr 8: 143.02 – 143.02 MbChr 15: 74.83 – 74.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[9] Further research is required to validate Ly6E for translation research. [1]

References

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  1. ^ a b c ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022587Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. doi:10.4049/jimmunol.157.3.969. PMID 8757598.
  6. ^ Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. Bibcode:1996PNAS...93.5910M. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
  7. ^ "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
  8. ^ Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
  9. ^ Hossiny MA, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

Further reading

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